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 Formulary Chapter 5: Infections - Full Chapter
Notes:

View the UHS antimicrobial guideline here

View the South Central Antimicrobial Network guidelines for antibiotic prescribing in the community here

Chapter Links...
 Details...
05.01  Antibacterial drugs
Taurolidine  (Taurolock®)
(solution)
View adult BNF View childrens BNF
Formulary
Red

For use as a line lock in patients on long-term TPN or IV fluids

 
   
Taurolidine, citrate and heparin  (TauroLock-Hep500®)
(solution)
View adult BNF View childrens BNF
Formulary
Red

For use as a line lock in patients on long-term TPN or IV fluids

 
   
05.01.01  Penicillins
05.01.01.01  Benzylpenicillin and phenoxymethylpenicillin
Benzathine benzylpenicillin
(intramuscular injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Special Use by Sexual Health Clinics (Solent NHS Trust) ONLY 

For treatment of syphilis as recommended in BASHH Guidelines 2015

note The preparation is strictly for deep intramuscular injection

 
   
Benzylpenicillin sodium (Penicillin G)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Phenoxymethylpenicillin (penicillin V)
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.01.01.02  Penicillinase-resistant penicillins
Flucloxacillin
(capsule/liquid/injection)
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Formulary
Green
 
   
Temocillin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Specialist use only

 
   
05.01.01.03  Broad-spectrum penicillins to top
Amoxicillin
(capsule/sachet/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Red for patients with chronic low back pain associated with Modic type 1 changes

 
   
Co-Amoxiclav
(tablet/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.01.01.04  Antipseudomonal penicillins
Piperacillin and Tazobactam
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Ticarcillin with clavulanic acid
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

unlicensed Specialist use only

 
   
05.01.01.05  Mecillinams
Pivmecillinam
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Microbiology recommendation only

 
   
05.01.02  Cephalosporins, carbapenems and other beta-lactums
05.01.02  Cephalosporins
05.01.02.01  Cephalosporins to top
Cefaclor
(capsule/modified release tablet/liquid)
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Formulary
Green
 
   
Cefalexin
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Cefazolin
(injection)
View adult BNF View childrens BNF
Formulary
Red

Restricted Item Use restricted to Microbiology recommendation only for MSSA bacteraemia in patients with mild penicillin allergy who are not suitable for treatment with flucloxacillin.

SPC and PIL available on MHRA website.

 
   
Cefixime
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cefotaxime
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cefoxitin
(injection)
View adult BNF View childrens BNF
Formulary
Red

unlicensed Unlicensed

Restricted Item Microbiology recommendation only for mycobactrium abcessus respiratory infection in cystic fibrosis

 
   
Ceftaroline
(injection)
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Formulary
Red

Restricted Item Microbiology recommendation only

 
   
Ceftazidime
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Ceftazidime/avibactamBlack Triangle
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item  restricted to microbiology approval/recommendation only

 
   
Ceftolozane/tazobactam  (Zerbaxa®)
(injection)
View adult BNF View SPC online
Formulary
Red

Restricted Item  restricted to microbiology approval/recommendation only

 
   
Ceftriaxone
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cefuroxime
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.01.02.02  Carbapenems
Ertapenem
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Imipenem with Cilastatin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Meropenem
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.01.02.03  Other beta-lactums antibiotics
Aztreonam
(injection/nebuliser solution)
View adult BNF View SPC online View childrens BNF
Formulary
Red Specialist Centre
High Cost Medicine

To be used in line with NHSE specialised commissioning policy

 
   
05.01.03  Tetracyclines
Demeclocycline
(capsules)
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Formulary
Amber Initiation

For the treatment of SIADH

 
   
Doxycycline
(capsule/dispersible tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Dispersible tablets only if cannot swallow caps

 
   
Doxycycline
(injection)
View adult BNF View childrens BNF
Formulary
Red

unlicensed unlicensed

 
   
Lymecycline
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Restricted Item Dermatology only

 
   
Oxytetracycline
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Tigecycline
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

unlicensed Specialist use only

 
   
05.01.04  Aminoglycosides
Amikacin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Gentamicin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Neomycin Sulphate
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Cancer care for gut sterilisation prior to BMT

unlicensed Liquid is unlicensed

 
   
Tobramycin
(Nebules)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
High Cost Medicine

Restricted Item Specialist use only

 
   
Tobramycin
(injection/dry powder inhaler)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Dry powder inhaler specialist use only

 
Link  NICE TA 276 - Dry powder inhalers for pseudomonas lung infection in cystic fibrosis
   
05.01.05  Macrolides to top
Azithromycin
(capsule/tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Azithromycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Clarithromycin
(tablet/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Erythromycin
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.01.06  Clindamycin
Clindamycin
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green

unlicensed Liquid is unlicensed

 
   
Clindamycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.01.07  Some other antibacterials
Dalbavancin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item For use only when recommended by microbiology/infectious disease consultant

 
   
05.01.07  Chloramphenicol
Chloramphenicol
(capsule/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Capsules on microbiology advice only

 
   
05.01.07  Fosfomycin
Fosfomycin
(sachets)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Prescribe as Monuril sachets in primary care

 
   
05.01.07  Fusidic acid to top
Sodium fusidate/fusidic acid
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.01.07  Vancomycin and teicoplanin
Teicoplanin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Vancomycin
(capsules)
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Formulary
Amber Recommended
 
   
Vancomycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Injection only to be used orally when capsules are unable to be given 

 
   
05.01.07  Daptomycin
Daptomycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Specialist use only

 
   
05.01.07  Linezolid
Linezolid
(tablet/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Specialist use only. Only to be used in primary care under microbiologist recommendation.  Specialist to advise of any monitoring or potential drug interactions.

Liquid for patients unable to swallow tabs.

 
   
05.01.07  Polymyxins
Colistimethate
(dry powder inhaler)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA 276 - Dry powder inhalers for pseudomonas lung infection in cystic fibrosis
   
Colistimethate
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation

injection can be nebulised

 
   
Colistimethate
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Cancer care only, for gut sterilisation prior to BMT

 
   
05.01.07  Rifaximin to top
Rifaximin
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary

Amber for hepatic encephalopathy

Red Third line treatment for small intestine bacterial overgrowth. Specialist use only as per UHS guideline

 
Link  DPC Shared Care Guideline for Rifaximin (revised Oct 2018)
Link  NICE TA 337 - Rifaximin for preventing episodes of overt hepatic encephalopathy
   
05.01.07  Fidaxomicin
Fidaxomicin
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended

Restricted Item Microbiology recommendation only for first episode of severe Clostridium difficile when concurrent antibiotics cannot be stopped and for second episodes of Clostridium difficile.

 
   
05.01.08  Sulphonamides and trimethoprim
Co-trimoxazole
(tablet/liquid/injection)
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Formulary
Amber Recommended
 
   
Sulfamethoxypyridazine (sulphamethoxypyridazine)
(tablet)
Formulary
Amber Recommended

Restricted Item Dermatology only

unlicensed Unlicensed

 
   
Trimethoprim
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.01.09  Antituberculosis drugs
BedaquilineBlack Triangle (Sirturo®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
NHS England
BlueTeq

Restricted Item For specialist use only in line with NHS Engand Clinical Commissioning Policy (170132P).

 
   
Clofazimine
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red

unlicensed Unlicensed

Restricted Item Specialist microbiology/TB service recommendation only

 
   
Cycloserine
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Specialist microbiology/TB service recommendation only

 
   
DelamanidBlack Triangle (Deltyba®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
NHS England
BlueTeq

Restricted Item For specialist use only in line with NHS England Clinical Commissioning Policy (170132P).

 
   
Ethambutol
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Isoniazid
(tablet/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

unlicensed Liquid is unlicensed

 
   
Pyrazinamide
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Rifabutin
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red

For mycobacterium avium prophylaxis

 
   
Rifampicin and Isoniazid
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Rifampicin, Isoniazid and Pyrazinamide (Rifater®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Rifampicin, isoniazid, pyrazinamide and ethambutol (Voractiv®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Streptomycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

unlicensed unlicensed

 
   
05.01.10  Antileprotic drugs
Dapsone
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
Rifampicin
(capsule/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary

Red Red for tuberculosis
Amber Amber for other infections

 
   
05.01.11  Metronidazole and tinidazole to top
Metronidazole
(tablet/liquid/suppository/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.01.12  Quinolones
Ciprofloxacin
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Ciprofloxacin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Levofloxacin
(tablet/injection)
View adult BNF View SPC online View childrens BNF
Formulary

Red Restricted Item Tablets/injection red for prophylaxis in multiple myeloma in line with UHS guidance (12 weeks treatment). Haematology only.
Green Restricted Item Tablets green for H pylori eradication in line with SCAN community antibiotic guidelines (note: not a first-line option)

 
   
LevofloxacinBlack Triangle (Quinsair®)
(nebuliser solution)
View adult BNF View SPC online View childrens BNF
Formulary
Red Specialist Centre
NHS England

Restricted Item For use only in accordance with Aug 2018 NHS England Clinical Commissioning Policy for chronic Pseudomonas lung infection in cystic fibrosis (adults)

 
   
Moxifloxacin
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
 
   
Moxifloxacin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Norfloxacin
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Ofloxacin
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Ofloxacin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.01.13  Nitrofurantoin
Nitrofurantoin
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.02  Antifungal drugs
05.02  Drugs used in fungal infections
05.02.01  Triazole antifungals to top
Fluconazole
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Fluconazole
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Isavuconazole (Cresemba®)
(capsules/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
BlueTeq
 
   
Itraconazole
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Itraconazole
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Posaconazole
(liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

 
   
Voriconazole
(tablet/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

 
   
05.02.02  Imidazole antifungals
Ketoconazole
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Restricted Item Specialist use only

unlicensed unlicensed

MHRA - Oral ketoconazole: do not prescribe or use for fungal infections—risk of liver injury outweighs benefits

 
   
05.02.03  Polyene antifungals
Amphotericin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Amphotericin (e.g. Abelcet® AmBisome®)
(injection - lipid formulation)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Specify brand

 
   
05.02.04  Echinocandin antifungals
Caspofungin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

 
   
Micafungin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

 
   
05.02.05  Other antifungals
Flucytosine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Terbinafine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.03  Antiviral drugs to top
RemdesivirBlack Triangle
(Injection)
Formulary
Red
BlueTeq

unlicensed Unlicensed Medicine

Yellow Card Yellow Card Reporting (Adverse Drug Reactions)

Restricted Item For use only in the treatment of patients hopitalised with suspected or laboratory-confirmed SARS-CoV-2 infection who meet the clinical criteria.

See Management of COVID-19 patients (via UHS staffnet) for the treatment and supply process

 
Link  Management of COVID-19 patients: Remdesivir treatment and supply (UHS only)
Link  MHRA Early access to medicines scheme (EAMS) scientific opinion May 2020
Link  NICE ES27: Remdesivir for treating hospitalised patients with suspected or confirmed COVID-19 Jun 2020
   
05.03.01  HIV infection
Cobicistat (Tybost®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item Specialist only, in line with NHSE Clinical Commissioning Policy F03/P/b

 
   
Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide fumarate  (Genvoya®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item Specialist only, in line with NHSE Clinical Commissioning Policies 16043/P and F/03/P/b

 
   
Emtricitabine/rilpivirine/tenofovir alafenamide fumarate (Odefsey®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item Specialist only, in line with NHSE Clinical commissioning policy 16043/P

 
   
05.03.01  Nucleoside reverse transcriptase inhibitors
Abacavir
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Abacavir/lamivudine (Kivexa®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Abacavir/lamivudine/zidovudine (Tizivir®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Bictegravir / emtricitabine / tenofovir-alafenamide (Biktarvy ®)
(tablets)
View adult BNF View SPC online View childrens BNF
Restricted Drug Restricted
Red
High Cost Medicine
NHS England

Specialist only, in line with NHSE Clinical Commissioning Policy 170131P

 
   
Darunavir/cobicistat/emtricitabine/tenofovir alafenamide fumarate  (Symtuza®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item Specialist only, in line with NHSE Clinical Commissioning Policy F03/P/b

 
   
Didanosine
(tablet/enteric coated capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Efavirenz/emtricitabine/tenofovir disoproxil fumarate  (Atripla®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (Stribild®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item Specialist only, in line with NHSE Clinical Commissioning Policy F03/P/b

 
   
Emtricitabine
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Emtricitabine/rilpivirine/tenofovir disoproxil fumarate (Eviplera®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item Specialist use only. Refer to NHS England Drugs List 

 
   
Emtricitabine/tenofovir alafenamide fumarate (Descovy®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
NHS England

Restricted Item Specialist only, in line with NHSE Clinical Commissioning Policy 16043/P

 
   
Emtricitabine/tenofovir disoproxil fumarate
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item When Zidovudine/lamivudine is unsuitable

 
   
Lamivudine
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Lamivudine/abacavir/dolutegravir (Triumeq®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Stavudine
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Tenofovir disoproxil fumarate
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
Link  NICE TA173: Hepatitis B (chronic) - tenofovir disoproxil
   
Zidovudine
(capsule/liquid/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Zidovudine/lamivudine
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
05.03.01  Protease inhibitors
Atazanavir
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Atazanavir sulfate/cobicistat (Evotaz®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

As per NHSE specialised commissioning circular 1614

 
   
Darunavir
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Darunavir/cobicistat (Rezolsta®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

As per NHSE specialised commissioning circular 1614

 
   
Fosamprenavir
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Lopinavir/ritonavir (Kaletra®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England

Restricted Item For use in licensed indications only.

Not for use in Covid-19 treatment outside of clinical trials. Seek further advice from infection control specialist/pharmacy team.

 
Link  NHS England/UK Chief Medical Officers’ joint letter: Novel coronavirus: clinical trials April 2020
   
Ritonavir
(tablet/oral suspension)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Saquinavir
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
05.03.01  Non-nucleoside reverse transcriptase inhibitors
Efavirenz
(tablet/capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Etravirine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Nevirapine
(tablet/liquid/MR tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Rilpivirine hydrochloride
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
05.03.01  Other antiretrovirals to top
Dolutegravir
(tablet)
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Formulary
Red
High Cost Medicine
NHS England
 
   
Dolutegravir sodium/lamivudine (Dovato®)
(tablets)
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Formulary
Red

Restricted Item For specialist use only.

For the treatment of Human Immunodeficiency Virus (HIV-1) infected adults and adolescents over 12 years of age

 
Link  NHSE Clinical Commissioning Policy Ref 200301P
   
Dolutegravir sodium/rilpivirine hydrochlorideBlack Triangle (Juluca®)
(tablets)
View adult BNF View SPC online
Formulary
Red

For the treatment of Human Immunodeficiency Virus (HIV-1) infected adults

 
Link  NHSE Clinical Commissioning Policy Ref 200210P
   
Maraviroc (Celsentri®)
(tablets/oral solution)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
Raltegravir
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
   
05.03.02  Herpesvirus infections
05.03.02.01  Herpes simplex and varicella-zoster infection
Aciclovir
(tablet/dispersible tablet/liquid)
View adult BNF View SPC online View childrens BNF
First Choice
Green
 
Valaciclovir
(tablet)
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Second Choice
Green
 
   
Aciclovir
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.03.02.02  Cytomegalovirus infection
Cidofovir
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item For use as per commissioning criteria set by NHS England

 
   
Foscarnet Sodium
(injection)
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Formulary
Red
High Cost Medicine
 
   
Ganciclovir
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
   
LetermovirBlack Triangle (Prevymis®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA591: Letermovir for preventing cytomegalovirus disease after a stem cell transplant
   
Valganciclovir
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
   
05.03.03  Viral hepatitis
Interferon alfa
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
   
Peginterferon alfa-2a (Pegasys®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Interferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA96: Adefovir dipivoxil and peginterferon alfa-2a for the treatment of chronic hepatitis B
   
Peginterferon Alfa-2b (ViraferonPeg®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Interferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
   
05.03.03.01  Chronic hepatitis B to top
Adefovir Dipivoxil
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA96: Adefovir dipivoxil and peginterferon alfa-2a for the treatment of chronic hepatitis B
   
Entecavir
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA153: Entecavir for the treatment of chronic hepatitis B
   
05.03.03.02  Chronic hepatitis C
Daclatasvir Black Triangle
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA364: Daclatasvir for treating chronic hepatitis C
   
DasabuvirBlack Triangle
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Elbasvir with grazoprevirBlack Triangle (Zepatier®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA413: Elbasvir–grazoprevir for treating chronic hepatitis C
   
Glecaprevir with pibrentasvirBlack Triangle (Maviret®)
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA499: Glecaprevir–pibrentasvir for treating chronic hepatitis C
   
Ledipasvir with sofosbuvirBlack Triangle (Harvoni®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA363: Ledipasvir–sofosbuvir for treating chronic hepatitis C
   
Ombitasvir/ paritaprevir/ ritonavirBlack Triangle (Viekirax®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA365: Ombitasvir–paritaprevir–ritonavir with or without dasabuvir for treating chronic hepatitis C
   
Ribavirin
(tablet/capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA106: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA200: Hepatitis C - peginterferon alfa and ribavirin
Link  NICE TA300: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
   
SimeprevirBlack Triangle
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA331: Simeprevir with peginterferon alfa & ribavirin for hepatitis C
   
SofosbuvirBlack Triangle
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA330: Sofosbuvir for treating chronic hepatitis C
   
Sofosbuvir with velpatasvirBlack Triangle (Epclusa®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA430 : Sofosbuvir–velpatasvir for treating chronic hepatitis C
   
Sofosbuvir/velpatasvir/voxilaprevirBlack Triangle (Vosevi)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA 507: Sofosbuvir–velpatasvir–voxilaprevir for treating chronic hepatitis C
   
05.03.04  Influenza
Oseltamivir
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Restricted Item In line with NICE TAs or pandemic flu

 
Link  NICE TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
Zanamivir
(inhalation)
View adult BNF View SPC online View childrens BNF
Formulary
Green

Restricted Item In line with NICE TAs or pandemic flu

 
Link  NICE TA158: Oseltamivir, amantadine (review) and zanamivir for the prophylaxis of influenza
Link  NICE TA168: Amantadine, oseltamivir and zanamivir for the treatment of influenza
   
ZanamivirBlack Triangle (Dectova®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

For treatment of complicated and potentially life-threatening influenza A or B virus infection in accordance with official guidance

 
Link  PHE Seasonal influenza: managing cases in critical care units (updated 2019)
Link  PHE: Guidance on use of antiviral agents for the treatment and prophylaxis of seasonal influenza (updated 2019)
   
05.03.05  Respiratory syncytial virus
Palivizumab (Synagis®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq

Restricted Item Commissioned by NHS England (for RSV prophylaxis) for children in the groups outlined in Specialised Commissioning Circular 1937.

 
Link  Green Book Chapter 27a Respiratory syncytial virus
   
Ribavirin
(injection/inhalation)
View adult BNF View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only 

unlicensed Injection is unlicensed

 
   
05.04  Antiprotozoal drugs
05.04.01  Antimalarials to top
 note 
  • Treatment only on formulary.
  • Prophylaxis for travellers should be prescribed privately.
  • Seek expert advice for other protozoal infestations.
05.04.01  Treatment of malaria
Artesunate
(injection)
View adult BNF View childrens BNF
Formulary
Red

unlicensed unlicensed

Restricted Item for severe or complicated P.falciparum malaria

 
   
05.04.01  Artemether with lumefantrine
Artemether with lumefantrine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red

For acute uncomplicated P.falciparum malaria or as oral step down treatment following IV artesunate

 
   
05.04.01  Chloroquine
Chloroquine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended

Restricted Item Supported only for licensed indications (Not NHS not on NHS for malaria prevention)

 

Not for use in Covid-19 treatment/prevention outside of clinical trials (see links below). Seek further advice from infection control specialist/pharmacy team.

 
Link  EMA statement: COVID-19: chloroquine and hydroxychloroquine only to be used in clinical trials or emergency use programmes April 2020
Link  MHRA Advice March 2020: Do not use hydroxychlorquine or chloroquine for Covid-19 treatment except within a clinical trial
Link  NHS England/UK Chief Medical Officers’ joint letter: Novel coronavirus: clinical trials April 2020
Link  NPA Advice for Pharmacists on sales or supply of chloroquine/hydroxychloroquine for Covid-19 treatment/prevention
   
05.04.01  Mefloquine
Mefloquine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
05.04.01  Primaquine to top
Primaquine
(tablet)
View adult BNF View childrens BNF
Formulary
Amber Recommended

unlicensed unlicensed

Restricted Item microbiology recommendation only

 
   
05.04.01  Proguanil
Proguanil Hydrochloride with Atovaquone (Malarone®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
05.04.01  Pyrimethamine
Pyrimethamine with Sulfadoxine
(tablet)
View adult BNF View childrens BNF
Formulary
Amber Recommended

unlicensed unlicensed

 
   
05.04.01  Quinine
Quinine dihydrochloride
(injection)
View adult BNF View childrens BNF
Formulary
Red

unlicensed unlicensed

 
   
Quinine sulfate
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
05.04.01  Tetracyclines
Doxycycline
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
05.04.04  Antigiardial drugs to top
Mepacrine Hydrochloride
View adult BNF View SPC online View childrens BNF
Formulary
Red

For discoid lupus erythematosus

 unlicensed unlicensed

 
   
05.04.07  Drugs for toxoplasmosis
 note 

Seek expert advice

Pyrimethamine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Sulfadiazine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.04.08  Drugs for pneumocystis pneumonia
Co-trimoxazole
(tablet/liquid/injection)
View adult BNF View SPC online View childrens BNF
First Choice
Red
 
Atovaquone
(liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Clindamycin
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red

In combination with primaquine (off-label use)

unlicensed Liquid is unlicensed

 
   
Dapsone
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Pentamidine Isetionate
(Nebulised/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Primaquine
(tablet)
View adult BNF View childrens BNF
Formulary
Red

unlicensed unlicensed

 
   
Trimethoprim
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
05.05  Anthelmintics
Albendazole
(tablet)
View adult BNF View childrens BNF
Formulary
Red

unlicensed unlicensed

 
   
05.05.01  Drugs for threadworms
Mebendazole
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
05.05.02  Ascaricides to top
05.05.03  Drugs for tapeworm infections
05.05.04  Drugs for hookworms
05.05.05  Schistosomicides
05.05.06  Filaricides
05.05.07  Drugs for cutaneous larva migrans to top
05.05.08  Drugs for strongyloidiasis
 ....
 Non Formulary Items
Ampicillin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Boceprevir
(capsule)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine

Withdrawn from marketing in the UK

Link  NICE TA253: Boceprevir for the treatment of genotype 1 chronic hepatitis C
 
Co-Fluampicil

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Famciclovir
(tablets)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Minocycline
(tablets/MR capsules)

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NICE: Minocycline safety concerns
 
Piperazine
(With sennosides)

View adult BNF View SPC online View childrens BNF
Non Formulary

Withdrawn from marketing in the UK

 
Sulfapyridine  (sulphapyridine)
(capsules)

Non Formulary

unlicensed unlicensed

 
Telaprevir
(tablet)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine

Withdrawn from marketing in the UK

Link  NICE TA252: Telaprevir for the treatment of genotype 1 chronic hepatitis C
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine

Traffic Light Status Information

Status Description

Green

Suitable for prescribing by all in both primary and secondary care.  

Amber Recommended

Specialist recommended but suitable for continuation in primary care.  

Amber Initiation

Specialist initiated but suitable for continuation in primary care.  

Amber SCG

Specialist initiated and for continuation in primary care under a locally approved shared care guideline.  

Red

Suitable for prescribing in specialist settings (secondary care) only.   

Red Specialist Centre

Secondary care medicines to be used under specialised commissioning arrangements only.  

Blue

For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy.  

Black

Not recommended for use.  

netFormulary