netFormulary NHS
Southampton Joint Formulary
 Search
 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
Chapter Links...
 Details...
08.01  Cytotoxic drugs
08.01  Drugs for cytotoxic-induced side-effects
Calcium Folinate
(tablet/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

folinic acid rescue

 
   
Dexrazoxane (Cardioxane®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red Specialist Centre
High Cost Medicine
NHS England

Restricted Item Approved only for preventing cardiotoxicity in children and young people (under 25 years) receiving high-dose anthracyclines in accordance with NHS England Commissioning Policy.

 

Red Triangle Note: Savene® brand remains non-formulary

 
Link  NHS England specialised clinical commissioning policy Ref 200204P
   
Mesna
(tablet/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

For urothelial toxicity

 
   
08.01.01  Alkylating drugs
Bendamustine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA216: Bendamustine for the first-line treatment of chronic lymphocytic leukaemia
   
Cytotoxic Drug Busulfan
(tablet/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

injection for BMT only

 
   
Cytotoxic Drug Carmustine
(injection/implants)
View adult BNF View SPC online View childrens BNF
Formulary
Red

unlicensed Injection is unlicensed

 
Link  NICE TA121: Carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma
   
Cytotoxic Drug Chlorambucil
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
 
   
Cytotoxic Drug Cyclophosphamide
(tablet/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Ifosfamide
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Lomustine
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Melphalan
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
 
   
Cytotoxic Drug Melphalan
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Thiotepa
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red

For treatment of CNS diffuse large B cell lymphoma

 
   
Cytotoxic Drug Treosulfan (Trecondi®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Not appraised by NICE for use prior to alloHSCT in patients with non-malignant disease.

Note: Treosulfan (generic) is non-formulary for palliative treatment of epithelial ovarian cancer.

 
Link  NICE TA640: Treosulfan with fludarabine for malignant disease before allogenic stem cell transplant
   
08.01.02  Anthracyclines and other cytotoxic antibiotics
Cytotoxic Drug Bleomycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Dactinomycin
(injection)
View adult BNF View childrens BNF
Formulary
Red

unlicensed unlicensed

 
   
Cytotoxic Drug Daunorubicin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Doxorubicin
(injection/Liposomal injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Liposomal is a HCD high cost drug

 
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Epirubicin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Idarubicin
(capsule/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Mitomycin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Mitoxantrone
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Pixantrone
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA306: Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkins B‑cell lymphoma
   
08.01.03  Antimetabolites to top
Cytotoxic Drug Azacitidine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA218: Azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia
Link  NICE TA399: Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
   
Cytotoxic Drug Capecitabine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes C) colon cancer
Link  NICE TA191: Capecitabine for the treatment of advanced gastric cancer
Link  NICE TA61: Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer
   
Cytotoxic Drug Cladribine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
   
Cytotoxic Drug Cytarabine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Fludarabine Phosphate
(tablet/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA119: Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia
Link  NICE TA29: Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia
   
Cytotoxic Drug Fluorouracil
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Gemcitabine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA116: Gemcitabine for the treatment of metastatic breast cancer
Link  NICE TA25: Guidance on the use of gemcitabine for the treatment of pancreatic cancer
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Mercaptopurine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation

unlicensed 10mg tablets are unlicensed

 
   
Cytotoxic Drug Methotrexate (Haem/Onc)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Pemetrexed
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA135: Pemetrexed for the treatment of malignant pleural mesothelioma
Link  NICE TA181: Pemetrexed for the first-line treatment of non-small-cell lung cancer
Link  NICE TA190: Pemetrexed for the first-line treatment of non-small-cell lung cancer
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Cytotoxic Drug Tioguanine
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Trifluridine and tipiracil
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA405: Trifluridine–tipiracil for previously treated metastatic colorectal cancer
   
08.01.04  Vinca alkaloids and etoposide
Etoposide
(capsule/injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Vinblastine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Vincristine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Vinorelbine
(injection/capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
08.01.05  Other antineoplastic drugs
AbemaciclibBlack Triangle (Verzenios®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA563: abemaciclib for previously untreated, HR-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA579: Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy
   
AlectinibBlack Triangle (Alecensa®)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  TA536: Alectinib for untreated ALK-positive advanced non-small-cell lung cancer
   
Arsenic trioxide
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA526: Arsenic trioxide for treating acute promyelocytic leukaemia
   
Atezolizumab
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA 492: Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA 520: Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
Link  NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA584: Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer
Link  NICE TA638: Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancer
Link  NICE TA639: Atezolizumab with nab-paclitaxel for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancer
   
AvelumabBlack Triangle (Bavencio®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
NHS England

Also available via MHRA EAMS (1 Sept 2020) for off label use in adults with advanced urothelial carcinoma that has not progressed after an initial course of chemotherapy. 

 
Link  NICE TA517: Avelumab for treating metastatic Merkel cell carcinoma
Link  NICE TA645: Avelumab with axitinib for untreated advanced renal cell carcinoma
   
Bevacizumab (Avastin®)
(inj)
View adult BNF View SPC online View childrens BNF
Formulary
Red Specialist Centre
High Cost Medicine
Cancer Drugs Fund
BlueTeq

For use in line with CDF criteria.

Restricted Item Commissioned by NHS England for neurofibromatosis by NHS England as per national protocol (see NF2 service specification) at specialist centres only.

 
   
Blinatumomab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA450 : Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemia
Link  NICE TA589: Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activity
   
Cytotoxic Drug Bortezomib
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA129: Bortezomib monotherapy for relapsed multiple myeloma
Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
   
Brentuximab vedotin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA446 : Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA478: Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
Link  NICE TA524: Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA577: Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
Link  NICE TA641: Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphoma
   
Carfilzomib
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA457 : Carfilzomib for previously treated multiple myeloma
   
Cetuximab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA145: Cetuximab for the treatment of locally advanced squamous cell cancer of the head and neck
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
   
Crisantaspase
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Dacarbazine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
DaratumumabBlack Triangle (Darzalex®)
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
Link  NICE TA573: Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
   
Dinutuximab betaBlack Triangle (Qarziba®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA538: Dinutuximab beta for treating neuroblastoma
   
DurvalumabBlack Triangle (Imfinzi®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA578: Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation
   
EncorafenibBlack Triangle (Braftovi®)
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA562: with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma
   
EntrectinibBlack Triangle (Rozlytrek®)
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA643: Entrectinib for treating ROS1-positive advanced non-small-cell lung cancer
Link  NICE TA644: Entrectinib for treating NTRK fusion-positive solid tumours
   
Cytotoxic Drug Eribulin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
   
Cytotoxic Drug Gemtuzumab ozogamicinBlack Triangle (Mylotarg®)
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA545: Gemtuzumab ozogamicin for untreated acute myeloid leukaemia
   
GilteritinibBlack Triangle (Xospata®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA642: Gilteritinib for treating relapsed or refractory acute myeloid leukaemia
   
Cytotoxic Drug Hydroxycarbamide
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
 
   
Idelalisib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA359: Idelalisib for treating chronic lymphocytic leukaemia
   
Inotuzumab ozogamicinBlack Triangle (Besponsa®)
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq
 
Link  NICE TA 541: Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
   
Ipilimumab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
   
Cytotoxic Drug IxazomibBlack Triangle (Ninlaro®)
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA505: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
   
LenvatinibBlack Triangle (Kisplyx®; Lenvima®)
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red

note Lenvima for thyroid and hepatocellular carcinoma, Kisplyx for renal cell carcinoma

 
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
Link  NICE TA551: Lenvatinib for untreated advanced hepatocellular carcinoma
   
Cytotoxic Drug Liposomal daunorubicin-cytarabine (Vyxeos®)
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA552: Liposomal cytarabine-daunorubicin for untreated acute myeloid leukaemia
   
Lutetium (177Lu) oxodotreotride
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA539: Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours
   
Midostaurin
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA523: Midostaurin for untreated acute myeloid leukaemia
   
Mitotane
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red

palliative use in adrenal carcinoma

 
   
NivolumabBlack Triangle (Opdivo®)
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund

For untreated advanced renal cell carcinoma: available through Cancer Drugs Fund, only if conditions in the managed access agreement are followed.

 
Link  NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
Link  NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
Link  NICE TA462 : Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA483: Nivolumab for previously treated squamous non-small-cell lung cancer
Link  NICE TA484: Nivolumab for previously treated non-squamous non-small-cell lung cancer
Link  NICE TA490:Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy
Link  NICE TA530:Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy
Link  NICE TA558: Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease
Link  NICE TA581: Nivolumab with ipilimumab for untreated advanced renal cell carcinoma
   
Olaparib (Lynparza®)
(capsules/tablets)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine
Cancer Drugs Fund

note Note: NICE TA598 and TA620 only cover use of tablet formulation (not capsules)

 
Link  NICE TA598: Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy
Link  NICE TA620: Olaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer in adults with a BRCA1 or BRCA2 mutation.
   
Olaratumab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA465: Olaratumab in combination with doxorubicin for treating advanced soft tissue sarcoma
   
Cytotoxic Drug Panitumumab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
   
Panobinostat
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
   
Pegaspargase (Oncaspar®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia
   
Pembrolizumab (Keytruda®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund

50mg powder for concentrate for solution for infusion is black triangle

Black  NICE TA650: Pembrolizumab with axitinib for untreated advanced renal cell carcinoma - not recommended

 
Link  NICE TA357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA519:Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA522: Pembrolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  NICE TA540: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA553: Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence
Link  NICE TA557: Pembrolizumab for untreated, metastatic, non-squamous non-small-cell lung cancer, with pemetrexed and platinum chemotherapy
Link  NICE TA600: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
   
Cytotoxic Drug Pertuzumab
(infusion)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
Link  NICE TA569: Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer
   
Cytotoxic Drug Polatuzumab vedotinBlack Triangle (Polivy®)
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  Polatuzumab vedotin (Polivy) with rituximab and bendamustine for treating relapsed or refractory diffuse large B cell lymphoma
   
Streptozocin
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

unlicensed unlicensed

Locally advanced and metastatic neuroendocrine tumours

 
   
Cytotoxic Drug Talimogene laherparepvecBlack Triangle (Imlygic®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Observe special precautions for handling and disposal (refer to SPC section 6.6)

 
Link  NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
   
Cytotoxic Drug Temozolomide
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
 
Link  NHS England Clinical Commissioning Policy Ref 200203P: For treatment of newly diagnosed anaplastic astrocytoma without 1p/19q codeletion following surgery and radiotherapy (adults)
Link  NICE TA121: Carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma
Link  NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
   
Cytotoxic Drug Trastuzumab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA107: Trastuzumab for the adjuvant treatment of early-stage HER2-positive breast cancer
Link  NICE TA208: Trastuzumab for the treatment of HER2-positive metastatic gastric cancer
Link  NICE TA257: Lapatinib or trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone-receptor-positive breast cancer that overexpresses HER2
Link  NICE TA34: Guidance on the use of trastuzumab for the treatment of advanced breast cancer
   
Cytotoxic Drug Trastuzumab emtansine
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA458 : Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
Link  NICE TA632: Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancer
   
Venetoclax (Venclyxto®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA487: Venetoclax for treating chronic lymphocytic leukaemia
Link  NICE TA561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
   
08.01.05  Platinum compounds
Cytotoxic Drug Carboplatin
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Cisplatin
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Oxaliplatin
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes C) colon cancer
   
08.01.05  Procarbazine
Cytotoxic Drug Procarbazine
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
08.01.05  Protein kinase inhibitors to top
Afatinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
   
Axitinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
   
Bosutinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
   
BrigatinibBlack Triangle (Alunbrig®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
   
Cabozantinib (Cabometyx®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516:Cabozantinib for treating medullary thyroid cancer
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
   
CeritinibBlack Triangle
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Crizotinib
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
Link  NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
   
Dacomitinib Black Triangle (Vizimpro®)
(film coated tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

 

 

 
Link  NICE TA595 Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
   
Dasatinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Erlotinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA227: Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer
Link  NICE TA258: Erlotinib for the first-line treatment of locally advanced or metastatic EGFR-TK mutation-positive non-small-cell lung cancer
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Everolimus (Afinitor®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA432:Everolimus for advanced renal cell carcinoma after previous treatment
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
   
Everolimus (Votubia®)
View adult BNF View SPC online View childrens BNF
Formulary
Red Specialist Centre
High Cost Medicine

For use as per commissioning criteria set by NHS England

 
   
Gefitinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA192: Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Ibrutinib (Imbruvica®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA491:Ibrutinib for treating Waldenstrom’s macroglobulinaemia
Link  NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
   
Imatinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA209:Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
Link  NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
Link  NICE TA425:Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
Link  NICE TA70: Guidance on the use of imatinib for chronic myeloid leukaemia
Link  NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
   
LarotrectinibBlack Triangle (Vitrakvi® )
(oral solution)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA630: Larotrectinib for treating NTRK fusion-positive solid tumours
   
LorlatinibBlack Triangle (Lorviqua®)
(tablet)
View adult BNF View SPC online
Formulary
Red
High Cost Medicine
 
Link  NICE TA628: Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancer
   
NeratinibBlack Triangle (Nerlynx®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA612: Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab
   
Nilotinib
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Nintedanib
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Vargatef branf for NSCLC, Ofev brand for IPF in line with NICE guidance (see links)

 
Link  NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
Link  NICE TA379: Nintedanib for treating idiopathic pulmonary fibrosis
   
Niraparib
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA528: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
   
Osimertinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
   
PalbociclibBlack Triangle (Ibrance®)
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA619: Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
   
Pazopanib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA215: Pazopanib for the first-line treatment of advanced renal cell carcinoma
   
Ponatinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
   
Regorafenib (Stivarga® )
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
   
RibociclibBlack Triangle (Kisqali®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA 496: Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA593: Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
   
RucaparibBlack Triangle (Rubraca®)
(tablets)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA611: Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer
   
Ruxolitinib (Jakavi®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Sorafenib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
   
Sunitinib
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma
Link  NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Tivozanib
(capsules)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA512:Tivozanib for treating advanced renal cell carcinoma
   
Trametinib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
Vemurafenib
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA269: Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanoma
   
Dabrafenib
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
08.01.05  Taxanes
Cabazitaxel
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
   
Cytotoxic Drug Docetaxel
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA101: Docetaxel for the treatment of hormone-refractory metastatic prostate cancer
Link  NICE TA109: Docetaxel for the adjuvant treatment of early node-positive breast cancer
   
Paclitaxel
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA389:Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA55: Guidance on the use of paclitaxel in the treatment of ovarian cancer
   
Cytotoxic Drug Paclitaxel - Albumin Bound
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
   
08.01.05  Topoisomerase I inhibitors
Cytotoxic Drug Irinotecan
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Topotecan
(injection/capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA183: Topotecan for the treatment of recurrent and stage IVB cervical cancer
Link  NICE TA184: Topotecan for the treatment of relapsed small-cell lung cancer
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Trabectedin
Cytotoxic Drug Trabectedin
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA185:Trabectedin for the treatment of advanced soft tissue sarcoma
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Tretinoin
Tretinoin
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
08.02  Drugs affecting the immune response to top
Basiliximab (Simulect®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA481: Immunosuppressive therapy for kidney transplant in adults
Link  NICE TA482:Immunosuppressive therapy for kidney transplant in children and young people
   
08.02.01  Antiproliferative immunosuppressants
Cytotoxic Drug Azathioprine
(tablet/capsules/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Amber SCG

unlicensed Liquid and capsules (10mg) are unlicensed

 
   
Azathioprine
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Mycophenolate mofetil
(tablet/capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Amber SCG
High Cost Medicine

Red Red for renal transplant
Amber Amber for all other indications

Second line for resistant nephrotic syndrome, SLE nephritis

 
Link  NICE TA481: Immunosuppressive therapy for kidney transplant in adults
Link  NICE TA482:Immunosuppressive therapy for kidney transplant in children and young people
   
Mycophenolate mofetil
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA481: Immunosuppressive therapy for kidney transplant in adults
Link  NICE TA482:Immunosuppressive therapy for kidney transplant in children and young people
   
08.02.02  Corticosteroids and other immunosuppressants
Antithymocyte immunoglobulin (rabbit)
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
   
Ciclosporin
(capsule/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
High Cost Medicine

Red Red for renal transplant
Amber Amber for all other indications

Specify brand

 
   
Ciclosporin
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Sirolimus
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
High Cost Medicine

Red Red for renal transplant
Amber Amber for liver transplant

 
   
Tacrolimus
(capsule/granule/modified release capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation

Red Red for renal transplant
Amber Amber for all other indications

Specify brand

Second line for resistant nephrotic syndrome

MR cap for continuation in established patients only

 
   
Tacrolimus
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red

Only for patients already receiving tacrolimus who become nil by mouth

 
   
08.02.03  Anti-lymphocyte monoclonal antibodies
Obinutuzumab
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA343: Obinutuzumab in combination with chlorambucil for untreated chronic lymphocytic leukaemia
Link  NICE TA472: Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
Link  NICE TA513: Obinutuzumab for untreated advanced follicular lymphoma
Link  NICE TA629: Obinutuzumab with bendamustine for treating follicular lymphoma after rituximab
   
Ofatumumab
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA344: Ofatumumab with chlorambucil or bendamustine for CLL
   
Rituximab/ rituximab biosimilar (MabThera®, Rixathon®, Truxima®) (Haematology)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

Also for ITP and refractory autoimmune haemolytic anaemia

note Specify brand.

Rixathon and Truxima black triangle

 
Link  NICE TA137: Rituximab for the treatment of relapsed or refractory stage III or IV follicular non-Hodgkin’s lymphoma
Link  NICE TA174: Rituximab for the first-line treatment of chronic lymphocytic leukaemia
Link  NICE TA193: Rituximab for the treatment of relapsed or refractory chronic lymphocytic leukaemia
Link  NICE TA226: Rituximab for the first-line maintenance treatment of follicular non-Hodgkin’s lymphoma
Link  NICE TA243: Rituximab for the first-line treatment of stage III-IV follicular lymphoma
Link  NICE TA308: Rituximab in combination with glucocorticoids for treating anti-neutrophil cytoplasmic antibody-associated vasculitis
   
08.02.04  Other immunomodulating drugs
Alemtuzumab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
NHS England
BlueTeq

For multiple sclerosis and used off-label for allogeneic BMT and peripheral blood SCT

 
Link  EMA Safety Update: Use of alemtuzumab restricted while review is ongoing Apr 2019
Link  NHS England Urgent Clinical Commissioning Policy Statement: Alemtuzumab for treating relapsing-remitting multiple sclerosis - third cycle (all stages) Aug 2018
Link  NICE TA312: Alemtuzumab for relapsing‑remitting multiple sclerosis
   
BCG bladder instillation
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
CemiplimabBlack Triangle (Libtayo)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
Cancer Drugs Fund
 
Link  NICE TA592: Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma
   
Dimethyl fumarate (Tecfidera®)
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA320: Dimethyl fumarate for multiple sclerosis
   
Fingolimod
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA254: Fingolimod for highly active relapsing remitting multiple sclerosis
   
Glatiramer acetate
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only for multiple sclerosis

 
Link  NICE TA32: Beta interferon and glatiramer acetate for the treatment of multiple sclerosis
Link  NICE TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Mifamurtide
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA235: Mifamurtide for the treatment of osteosarcoma
   
Natalizumab
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA127: Natalizumab for the treatment of adults with highly active relapsing–remitting multiple sclerosis
   
OcrelizumabBlack Triangle (Ocrevus®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
BlueTeq
 
Link  NICE TA533: Ocrelizumab for treating relapsing–remitting multiple sclerosis
Link  NICE TA585: Ocrelizumab for treating primary progressive multiple sclerosis
   
Teriflunomide
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA303: Teriflunomide for treating relapsing–remitting multiple sclerosis
   
08.02.04  Interferon Alfa to top
Interferon Alfa
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
   
Peginterferon Alfa-2a (Pegasys®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA96: Adefovir dipivoxil and peginterferon alfa-2a for the treatment of chronic hepatitis B
   
Peginterferon Alfa-2b (ViraferonPeg®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Interferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
   
08.02.04  Interferon beta
Interferon Beta
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

For use as per specialist commissioning criteria

 

Restricted Item Not for use in Covid-19 treatment outside of clinical trials. Seek further advice from infection control specialist/pharmacy team.

 
Link  NHS England/UK Chief Medical Officers’ joint letter: Novel coronavirus: clinical trials April 2020
Link  NICE TA32: Beta interferon and glatiramer acetate for the treatment of multiple sclerosis
Link  NICE TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Peginterferon Beta-1a (Plegridy®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

 
Link  NICE TA624: Peginterferon beta-1a for treating relapsing–remitting multiple sclerosis
   
08.02.04  Aldesleukin
08.02.04  Lenalidomide, pomalidomide, and thalidomide
Lenalidomide ( Revlimid®)
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA171: Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy
Link  NICE TA322: Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
Link  NICE TA586: Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib
Link  NICE TA587: Lenalidomide plus dexamethasone for previously untreated multiple myeloma
Link  NICE TA627: Lenalidomide with rituximab for previously treated follicular lymphoma
   
Pomalidomide (Imnovid®)
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
   
Thalidomide
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Also for renal cell carcinoma

 
Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
   
08.03  Sex hormones and hormone antagonists in malignant disease
08.03.01  Oestrogens to top
Diethylstilbestrol
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Ethinylestradiol
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
08.03.02  Progestogens
Medroxyprogesterone acetate
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Megestrol acetate
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
Norethisterone
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Green
 
   
08.03.03  Androgens
08.03.04  Hormone antagonists
08.03.04.01  Breast cancer
Anastrozole
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
Link  NICE TA112: Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
   
Exemestane
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
Link  NICE TA112: Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
   
Letrozole
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
Link  NICE TA112: Hormonal therapies for the adjuvant treatment of early oestrogen-receptor-positive breast cancer
   
Tamoxifen
(tablet/liquid)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended

Restricted Item Liquid restricted for patients unable to swallow tablets

 
   
08.03.04.02  Prostate cancer and gonadorelin analogues to top
 note 

See also section 6.7.2

The least costly Gonadotrophin-Releasing Hormone Analogue over the course of treatment and for the organisation administering it should be used for its licensed indications

Radium-223 dichloride
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Radiopharmaceutical to be administered only by authorised persons

 
Link  NICE TA412: Radium-223 dichloride for treating hormone-relapsed prostate cancer with bone metastases
   
08.03.04.02  Gonadorelin analogues
Degarelix (Firmagon®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
 
Link  NICE TA404: Degarelix for treating advanced hormone-dependent prostate cancer
   
08.03.04.02  Anti-androgens
Abiraterone
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA259: Abiraterone for castration-resistant metastatic prostate cancer previously treated with a docetaxel-containing regimen
Link  NICE TA387: Abiraterone for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
   
Bicalutamide
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
Cyproterone acetate
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
Enzalutamide (Xtandi®)
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine

Note: not recommended for treating high-risk hormone-relapsed non-metastatic prostate cancer in adults, in accordance with NICE TA580

 
Link  NICE TA316: Enzalutamide for metastatic hormone‑relapsed prostate cancer previously treated with a docetaxel‑containing regimen
Link  NICE TA377: Enzalutamide for treating metastatic hormone-relapsed prostate cancer before chemotherapy is indicated
   
Flutamide
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
Goserelin
(3.6mg/10.8mg implant)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
Leuprorelin acetate
(3.75mg depot injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
Triptorelin acetate/pamoate
(3mg/11.25mg/22.5mg depot injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Recommended
 
   
08.03.04.03  Somatostatin analogues
Lanreotide (Somatuline Autogel®)
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
High Cost Medicine

For self administration

 
   
Octreotide
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
High Cost Medicine
 
   
Octreotide (Sandostatin Lar®)
(injection)
View adult BNF View SPC online View childrens BNF
Formulary
Amber Initiation
High Cost Medicine

First choice for acromegaly

 
   
 ....
 Non Formulary Items
Aldesleukin  (Proleukin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Anamorelin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Anamorelin

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Begelomab  (Begedina®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Calcium Leofolinate  (Isovorin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Canakinumab  (Ilaris®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Cediranib  (Recentin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cytotoxic Drug  Clofarabine  (Evoltra®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Cobimetinib  (Cotellic®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NICE TA414: Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma
 
Cytotoxic Drug  Decitabine  (Dacogen®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA270: Leukaemia (acute myeloid ) - decitabine (terminated appraisal)
 
Dexrazoxane  (Savene®)
(injection)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine

Note: Cardioxane brand is formulary (see section 8.1)

 
Dinutuximab  (Unituxin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Disodium Folinate  (Sodiofolin®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Disodium levofolinate/ Levofolinic acid
(injection)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Estramustine Phosphate  (Estracyt®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Everolimus  (Certican®) (Transplant)
(tablet)

View adult BNF View SPC online View childrens BNF
Non Formulary
Black
High Cost Medicine
Link  NICE TA348: Everolimus for preventing organ rejection in liver transplantation
 
Fampridine

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Fulvestrant  (Faslodex®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NICE TA239: Fulvestrant for the treatment of locally advanced or metastatic breast cancer
 
Glasdegib Black Triangle  (Daurismo®)
(tablets)

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NICE TA646: Glasdegib with chemotherapy for untreated acute myeloid leukaemia (terminated appraisal)
 
Histrelin  (Vantas®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Lapatinib  (Tyverb®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
 
Necitumumab  (Portrazza®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA411: Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer
 
Nelarabine  (Atriance®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Pablociclib  (Ibrance®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Palifermin  (Kepivance®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cytotoxic Drug  Raltitrexed  (Tomudex®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Ramucirumab  (Cyramza®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA403: Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer
 
Rociletinib

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sonidegib  (Odomzo®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cytotoxic Drug  Temsirolimus  (Torisel®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
 
Toremifene  (Fareston®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cytotoxic Drug  Treosulfan
(injection/capsules)

View adult BNF View SPC online View childrens BNF
Non Formulary

Non-formulary for the palliative treatment of epithelial ovarian cancer 

 
Cytotoxic Drug  Vandetanib  (Caprelsa®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Cytotoxic Drug  Vinflunine  (Javlor®)

View adult BNF View SPC online View childrens BNF
Non Formulary
Link  NICE TA272: Urothelial tract carcinoma (transitional cell, advanced, metastatic) - vinflunine
 
Vosaroxin  (Qinprezo)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine

Traffic Light Status Information

Status Description

Green

Suitable for prescribing by all in both primary and secondary care.  

Amber Recommended

Specialist recommended but suitable for continuation in primary care.  

Amber Initiation

Specialist initiated but suitable for continuation in primary care.  

Amber SCG

Specialist initiated and for continuation in primary care under a locally approved shared care guideline.  

Red

Suitable for prescribing in specialist settings (secondary care) only.   

Red Specialist Centre

Secondary care medicines to be used under specialised commissioning arrangements only.  

Blue

For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy.  

Black

Not recommended for use.  

netFormulary