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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
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08.01.03  Expand sub section  Antimetabolites
Cytotoxic Drug Azacitidine
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA218: Azacitidine for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukaemia and acute myeloid leukaemia
Link  NICE TA399: Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts
   
Cytotoxic Drug Capecitabine
(tablet)
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Formulary
Red
 
Link  NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes C) colon cancer
Link  NICE TA191: Capecitabine for the treatment of advanced gastric cancer
Link  NICE TA61: Guidance on the use of capecitabine and tegafur with uracil for metastatic colorectal cancer
   
Cytotoxic Drug Cladribine
(injection)
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Formulary
Red
High Cost Medicine
 
   
Cytotoxic Drug Cytarabine
(injection)
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Formulary
Red
 
   
Cytotoxic Drug Fludarabine Phosphate
(tablet/injection)
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Formulary
Red
 
Link  NICE TA119: Fludarabine monotherapy for the first-line treatment of chronic lymphocytic leukaemia
Link  NICE TA29: Guidance on the use of fludarabine for B-cell chronic lymphocytic leukaemia
   
Cytotoxic Drug Fluorouracil
(injection)
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Formulary
Red
 
   
Cytotoxic Drug Gemcitabine
(injection)
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Formulary
Red
 
Link  NICE TA116: Gemcitabine for the treatment of metastatic breast cancer
Link  NICE TA25: Guidance on the use of gemcitabine for the treatment of pancreatic cancer
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
Cytotoxic Drug Mercaptopurine
(tablet)
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Formulary
Amber Initiation

unlicensed 10mg tablets are unlicensed

 
   
Cytotoxic Drug Methotrexate (Haem/Onc)
(injection)
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Formulary
Red
 
   
Cytotoxic Drug Pemetrexed
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA135: Pemetrexed for the treatment of malignant pleural mesothelioma
Link  NICE TA181: Pemetrexed for the first-line treatment of non-small-cell lung cancer
Link  NICE TA190: Pemetrexed for the first-line treatment of non-small-cell lung cancer
Link  NICE TA402: Pemetrexed maintenance treatment for non-squamous non-small-cell lung cancer after pemetrexed and cisplatin
   
Cytotoxic Drug Tioguanine
(tablet)
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Formulary
Red
 
   
Trifluridine and tipiracil
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA405: Trifluridine–tipiracil for previously treated metastatic colorectal cancer
   
 ....
 Non Formulary Items
Cytotoxic Drug  Clofarabine  (Evoltra®)

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Non Formulary
High Cost Medicine
 
Cytotoxic Drug  Decitabine  (Dacogen®)

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Non Formulary
High Cost Medicine
Link  NICE TA270: Leukaemia (acute myeloid ) - decitabine (terminated appraisal)
 
Nelarabine  (Atriance®)

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Non Formulary
High Cost Medicine
 
Cytotoxic Drug  Raltitrexed  (Tomudex®)

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Non Formulary
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
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Link to adult BNF
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Link to children's BNF
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Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine

Traffic Light Status Information

Status Description

Green

Suitable for prescribing by all in both primary and secondary care.  

Amber Recommended

Specialist recommended but suitable for continuation in primary care.  

Amber Initiation

Specialist initiated but suitable for continuation in primary care.  

Amber SCG

Specialist initiated and for continuation in primary care under a locally approved shared care guideline.  

Red

Suitable for prescribing in specialist settings (secondary care) only.   

Red Specialist Centre

Secondary care medicines to be used under specialised commissioning arrangements only.  

Blue

For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy.  

Black

Not recommended for use.  

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