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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
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08.01.05  Expand sub section  Other antineoplastic drugs
AbemaciclibBlack Triangle (Verzenios®)
(tablets)
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Link  NICE TA563: abemaciclib for previously untreated, HR-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA579: Abemaciclib with fulvestrant for treating hormone receptor-positive, HER2-negative advanced breast cancer after endocrine therapy
   
AlectinibBlack Triangle (Alecensa®)
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Link  TA536: Alectinib for untreated ALK-positive advanced non-small-cell lung cancer
   
Arsenic trioxide
(infusion)
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Link  NICE TA526: Arsenic trioxide for treating acute promyelocytic leukaemia
   
Atezolizumab
(infusion)
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Link  NICE TA 492: Atezolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA 520: Atezolizumab for treating locally advanced or metastatic non-small-cell lung cancer after chemotherapy
Link  NICE TA525: Atezolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA584: Atezolizumab in combination for treating metastatic non-squamous non-small-cell lung cancer
Link  NICE TA638: Atezolizumab with carboplatin and etoposide for untreated extensive-stage small-cell lung cancer
Link  NICE TA639: Atezolizumab with nab-paclitaxel for untreated PD-L1-positive, locally advanced or metastatic, triple-negative breast cancer
   
AvelumabBlack Triangle (Bavencio®)
(injection)
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NHS England

Also available via MHRA EAMS (1 Sept 2020) for off label use in adults with advanced urothelial carcinoma that has not progressed after an initial course of chemotherapy. 

 
Link  NICE TA517: Avelumab for treating metastatic Merkel cell carcinoma
Link  NICE TA645: Avelumab with axitinib for untreated advanced renal cell carcinoma
   
Bevacizumab (Avastin®)
(inj)
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BlueTeq

For use in line with CDF criteria.

Restricted Item Commissioned by NHS England for neurofibromatosis by NHS England as per national protocol (see NF2 service specification) at specialist centres only.

 
   
Blinatumomab
(injection)
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Link  NICE TA450 : Blinatumomab for previously treated Philadelphia-chromosome-negative acute lymphoblastic leukaemia
Link  NICE TA589: Blinatumomab for treating acute lymphoblastic leukaemia in remission with minimal residual disease activity
   
Cytotoxic Drug Bortezomib
(injection)
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Link  NICE TA129: Bortezomib monotherapy for relapsed multiple myeloma
Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
Link  NICE TA311: Bortezomib for induction therapy in multiple myeloma before high-dose chemotherapy and autologous stem cell transplantation
Link  NICE TA370: Bortezomib for previously untreated mantle cell lymphoma
   
Brentuximab vedotin
(injection)
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Link  NICE TA446 : Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA478: Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma
Link  NICE TA524: Brentuximab vedotin for treating CD30-positive Hodgkin lymphoma
Link  NICE TA577: Brentuximab vedotin for treating CD30-positive cutaneous T-cell lymphoma
Link  NICE TA641: Brentuximab vedotin in combination for untreated systemic anaplastic large cell lymphoma
   
Carfilzomib
(Injection)
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Link  NICE TA457 : Carfilzomib for previously treated multiple myeloma
   
Cetuximab
(injection)
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Link  NICE TA145: Cetuximab for the treatment of locally advanced squamous cell cancer of the head and neck
Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
Link  NICE TA473: Cetuximab for treating recurrent or metastatic squamous cell cancer of the head and neck
   
Crisantaspase
(injection)
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Cytotoxic Drug Dacarbazine
(injection)
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DaratumumabBlack Triangle (Darzalex®)
(infusion)
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Link  NICE TA510: Daratumumab monotherapy for treating relapsed and refractory multiple myeloma
Link  NICE TA573: Daratumumab with bortezomib and dexamethasone for previously treated multiple myeloma
   
Dinutuximab betaBlack Triangle (Qarziba®)
(injection)
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Link  NICE TA538: Dinutuximab beta for treating neuroblastoma
   
DurvalumabBlack Triangle (Imfinzi®)
(injection)
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Link  NICE TA578: Durvalumab for treating locally advanced unresectable non-small-cell lung cancer after platinum-based chemoradiation
   
EncorafenibBlack Triangle (Braftovi®)
(capsules)
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Link  NICE TA562: with binimetinib for unresectable or metastatic BRAF V600 mutation-positive melanoma
   
EntrectinibBlack Triangle (Rozlytrek®)
(capsules)
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Link  NICE TA643: Entrectinib for treating ROS1-positive advanced non-small-cell lung cancer
Link  NICE TA644: Entrectinib for treating NTRK fusion-positive solid tumours
   
Cytotoxic Drug Eribulin
(injection)
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Link  NICE TA423: Eribulin for treating locally advanced or metastatic breast cancer after 2 or more chemotherapy regimens
   
Cytotoxic Drug Gemtuzumab ozogamicinBlack Triangle (Mylotarg®)
(infusion)
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Link  NICE TA545: Gemtuzumab ozogamicin for untreated acute myeloid leukaemia
   
GilteritinibBlack Triangle (Xospata®)
(tablets)
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Link  NICE TA642: Gilteritinib for treating relapsed or refractory acute myeloid leukaemia
   
Cytotoxic Drug Hydroxycarbamide
(capsule)
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Amber Initiation
 
   
Idelalisib
(tablet)
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Link  NICE TA359: Idelalisib for treating chronic lymphocytic leukaemia
   
Inotuzumab ozogamicinBlack Triangle (Besponsa®)
(infusion)
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BlueTeq
 
Link  NICE TA 541: Inotuzumab ozogamicin for treating relapsed or refractory B-cell acute lymphoblastic leukaemia
   
Ipilimumab
(injection)
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Link  NICE TA268: Ipilimumab for previously treated advanced (unresectable or metastatic) melanoma
Link  NICE TA319: Ipilimumab for previously untreated advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
   
Cytotoxic Drug IxazomibBlack Triangle (Ninlaro®)
(capsule)
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Link  NICE TA505: Ixazomib with lenalidomide and dexamethasone for treating relapsed or refractory multiple myeloma
   
LenvatinibBlack Triangle (Kisplyx®; Lenvima®)
(capsules)
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note Lenvima for thyroid and hepatocellular carcinoma, Kisplyx for renal cell carcinoma

 
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
Link  NICE TA551: Lenvatinib for untreated advanced hepatocellular carcinoma
   
Cytotoxic Drug Liposomal daunorubicin-cytarabine (Vyxeos®)
(infusion)
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Link  NICE TA552: Liposomal cytarabine-daunorubicin for untreated acute myeloid leukaemia
   
Lutetium (177Lu) oxodotreotride
(infusion)
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Link  NICE TA539: Lutetium (177Lu) oxodotreotide for treating unresectable or metastatic neuroendocrine tumours
   
Midostaurin
(capsules)
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Link  NICE TA523: Midostaurin for untreated acute myeloid leukaemia
   
Mitotane
(tablet)
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Red

palliative use in adrenal carcinoma

 
   
NivolumabBlack Triangle (Opdivo®)
(infusion)
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For untreated advanced renal cell carcinoma: available through Cancer Drugs Fund, only if conditions in the managed access agreement are followed.

 
Link  NICE TA384: Nivolumab for treating advanced (unresectable or metastatic) melanoma
Link  NICE TA400: Nivolumab in combination with ipilimumab for treating advanced melanoma
Link  NICE TA417: Nivolumab for previously treated advanced renal cell carcinoma
Link  NICE TA462 : Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA483: Nivolumab for previously treated squamous non-small-cell lung cancer
Link  NICE TA484: Nivolumab for previously treated non-squamous non-small-cell lung cancer
Link  NICE TA490:Nivolumab for treating squamous cell carcinoma of the head and neck after platinum-based chemotherapy
Link  NICE TA530:Nivolumab for treating locally advanced unresectable or metastatic urothelial cancer after platinum-containing chemotherapy
Link  NICE TA558: Nivolumab for adjuvant treatment of completely resected melanoma with lymph node involvement or metastatic disease
Link  NICE TA581: Nivolumab with ipilimumab for untreated advanced renal cell carcinoma
   
Olaparib (Lynparza®)
(capsules/tablets)
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note Note: NICE TA598 and TA620 only cover use of tablet formulation (not capsules)

 
Link  NICE TA598: Olaparib for maintenance treatment of BRCA mutation-positive advanced ovarian, fallopian tube or peritoneal cancer after response to first-line platinum-based chemotherapy
Link  NICE TA620: Olaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or primary peritoneal cancer in adults with a BRCA1 or BRCA2 mutation.
   
Olaratumab
(injection)
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Red
 
Link  NICE TA465: Olaratumab in combination with doxorubicin for treating advanced soft tissue sarcoma
   
Cytotoxic Drug Panitumumab
(injection)
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Link  NICE TA439 : Cetuximab and panitumumab for previously untreated metastatic colorectal cancer
   
Panobinostat
(tablet)
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Link  NICE TA380: Panobinostat for treating multiple myeloma after at least 2 previous treatments
   
Pegaspargase (Oncaspar®)
(injection)
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Link  NICE TA408: Pegaspargase for treating acute lymphoblastic leukaemia
   
Pembrolizumab (Keytruda® )
(injection)
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Red
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Cancer Drugs Fund

50mg powder for concentrate for solution for infusion is black triangle

 
Link  NICE TA357: Pembrolizumab for treating advanced melanoma after disease progression with ipilimumab
Link  NICE TA366: Pembrolizumab for advanced melanoma not previously treated with ipilimumab
Link  NICE TA428: Pembrolizumab for treating PD-L1-positive non-small-cell lung cancer after chemotherapy
Link  NICE TA519:Pembrolizumab for treating locally advanced or metastatic urothelial carcinoma after platinum-containing chemotherapy
Link  NICE TA522: Pembrolizumab for untreated locally advanced or metastatic urothelial cancer when cisplatin is unsuitable
Link  NICE TA531: Pembrolizumab for untreated PD-L1-positive metastatic non-small-cell lung cancer
Link  NICE TA540: Pembrolizumab for treating relapsed or refractory classical Hodgkin lymphoma
Link  NICE TA553: Pembrolizumab for adjuvant treatment of resected melanoma with high risk of recurrence
Link  NICE TA557: Pembrolizumab for untreated, metastatic, non-squamous non-small-cell lung cancer, with pemetrexed and platinum chemotherapy
Link  NICE TA600: Pembrolizumab with carboplatin and paclitaxel for untreated metastatic squamous non-small-cell lung cancer
   
Cytotoxic Drug Pertuzumab
(infusion)
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Link  NICE TA424: Pertuzumab for the neoadjuvant treatment of HER2-positive breast cancer
Link  NICE TA509: Pertuzumab with trastuzumab and docetaxel for treating HER2-positive breast cancer
Link  NICE TA569: Pertuzumab for adjuvant treatment of HER2-positive early stage breast cancer
   
Streptozocin
(injection)
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Red
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unlicensed unlicensed

Locally advanced and metastatic neuroendocrine tumours

 
   
Cytotoxic Drug Talimogene laherparepvecBlack Triangle (Imlygic®)
(injection)
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Observe special precautions for handling and disposal (refer to SPC section 6.6)

 
Link  NICE TA410: Talimogene laherparepvec for treating unresectable metastatic melanoma
   
Cytotoxic Drug Temozolomide
(capsule)
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NHS England
 
Link  NHS England Clinical Commissioning Policy Ref 200203P: For treatment of newly diagnosed anaplastic astrocytoma without 1p/19q codeletion following surgery and radiotherapy (adults)
Link  NICE TA121: Carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma
Link  NICE TA23: Guidance on the use of temozolomide for the treatment of recurrent malignant glioma (brain cancer)
   
Cytotoxic Drug Trastuzumab
(injection)
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Red
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Link  NICE TA107: Trastuzumab for the adjuvant treatment of early-stage HER2-positive breast cancer
Link  NICE TA208: Trastuzumab for the treatment of HER2-positive metastatic gastric cancer
Link  NICE TA257: Lapatinib or trastuzumab in combination with an aromatase inhibitor for the first-line treatment of metastatic hormone-receptor-positive breast cancer that overexpresses HER2
Link  NICE TA34: Guidance on the use of trastuzumab for the treatment of advanced breast cancer
   
Cytotoxic Drug Trastuzumab emtansine
(injection)
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Red
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Link  NICE TA458 : Trastuzumab emtansine for treating HER2-positive advanced breast cancer after trastuzumab and a taxane
Link  NICE TA632: Trastuzumab emtansine for adjuvant treatment of HER2-positive early breast cancer
   
Venetoclax (Venclyxto®)
(tablet)
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Red
 
Link  NICE TA487: Venetoclax for treating chronic lymphocytic leukaemia
Link  NICE TA561: Venetoclax with rituximab for previously treated chronic lymphocytic leukaemia
   
08.01.05  Expand sub section  Platinum compounds
Cytotoxic Drug Carboplatin
(Injection)
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Red
 
   
Cytotoxic Drug Cisplatin
(Injection)
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Red
 
   
Cytotoxic Drug Oxaliplatin
(Injection)
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Red
 
Link  NICE TA100: Capecitabine and oxaliplatin in the adjuvant treatment of stage III (Dukes C) colon cancer
   
08.01.05  Expand sub section  Procarbazine
Cytotoxic Drug Procarbazine
(capsule)
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Red
 
   
08.01.05  Expand sub section  Protein kinase inhibitors
Afatinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
   
Axitinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
   
Bosutinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
   
BrigatinibBlack Triangle (Alunbrig®)
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
   
Cabozantinib (Cabometyx®)
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516:Cabozantinib for treating medullary thyroid cancer
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
   
CeritinibBlack Triangle
(capsule)
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Red
High Cost Medicine
 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Crizotinib
(capsule)
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Red
High Cost Medicine
 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
Link  NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
   
Dacomitinib Black Triangle (Vizimpro®)
(film coated tablets)
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Red
High Cost Medicine

 

 

 
Link  NICE TA595 Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
   
Dasatinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Erlotinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA227: Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer
Link  NICE TA258: Erlotinib for the first-line treatment of locally advanced or metastatic EGFR-TK mutation-positive non-small-cell lung cancer
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Everolimus (Afinitor®)
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA432:Everolimus for advanced renal cell carcinoma after previous treatment
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
   
Everolimus (Votubia®)
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Red Specialist Centre
High Cost Medicine

For use as per commissioning criteria set by NHS England

 
   
Gefitinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA192: Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Ibrutinib (Imbruvica®)
(tablets)
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Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA491:Ibrutinib for treating Waldenstrom’s macroglobulinaemia
Link  NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
   
Imatinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA209:Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
Link  NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
Link  NICE TA425:Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
Link  NICE TA70: Guidance on the use of imatinib for chronic myeloid leukaemia
Link  NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
   
LarotrectinibBlack Triangle (Vitrakvi® )
(oral solution)
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Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA630: Larotrectinib for treating NTRK fusion-positive solid tumours
   
LorlatinibBlack Triangle (Lorviqua®)
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA628: Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancer
   
NeratinibBlack Triangle (Nerlynx®)
(tablets)
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Red
High Cost Medicine
 
Link  NICE TA612: Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab
   
Nilotinib
(capsule)
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Red
High Cost Medicine
 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Nintedanib
(capsule)
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Red
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Vargatef branf for NSCLC, Ofev brand for IPF in line with NICE guidance (see links)

 
Link  NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
Link  NICE TA379: Nintedanib for treating idiopathic pulmonary fibrosis
   
Niraparib
(capsules)
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Red
High Cost Medicine
 
Link  NICE TA528: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
   
Osimertinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
   
PalbociclibBlack Triangle (Ibrance®)
(capsules)
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Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA619: Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
   
Pazopanib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA215: Pazopanib for the first-line treatment of advanced renal cell carcinoma
   
Ponatinib
(tablet)
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Red
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Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
   
Regorafenib (Stivarga® )
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
   
RibociclibBlack Triangle (Kisqali®)
(tablets)
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Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA 496: Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA593: Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
   
RucaparibBlack Triangle (Rubraca®)
(tablets)
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Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA611: Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer
   
Ruxolitinib (Jakavi®)
(tablet)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Sorafenib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
   
Sunitinib
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma
Link  NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Tivozanib
(capsules)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA512:Tivozanib for treating advanced renal cell carcinoma
   
Trametinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
Vemurafenib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA269: Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanoma
   
Dabrafenib
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
08.01.05  Expand sub section  Taxanes to top
Cabazitaxel
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA391: Cabazitaxel for hormone-relapsed metastatic prostate cancer treated with docetaxel
   
Cytotoxic Drug Docetaxel
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA101: Docetaxel for the treatment of hormone-refractory metastatic prostate cancer
Link  NICE TA109: Docetaxel for the adjuvant treatment of early node-positive breast cancer
   
Paclitaxel
(Injection)
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Formulary
Red
 
Link  NICE TA389:Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
Link  NICE TA55: Guidance on the use of paclitaxel in the treatment of ovarian cancer
   
Cytotoxic Drug Paclitaxel - Albumin Bound
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA476: Paclitaxel as albumin-bound nanoparticles with gemcitabine for untreated metastatic pancreatic cancer
   
08.01.05  Expand sub section  Topoisomerase I inhibitors
Cytotoxic Drug Irinotecan
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
Cytotoxic Drug Topotecan
(injection/capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
Link  NICE TA183: Topotecan for the treatment of recurrent and stage IVB cervical cancer
Link  NICE TA184: Topotecan for the treatment of relapsed small-cell lung cancer
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Trabectedin
Cytotoxic Drug Trabectedin
(Injection)
View adult BNF View SPC online View childrens BNF
Formulary
Red
High Cost Medicine
 
Link  NICE TA185:Trabectedin for the treatment of advanced soft tissue sarcoma
Link  NICE TA389 - Topotecan, pegylated liposomal doxorubicin hydrochloride, paclitaxel, trabectedin and gemcitabine for treating recurrent ovarian cancer
   
08.01.05  Expand sub section  Tretinoin
Tretinoin
(capsule)
View adult BNF View SPC online View childrens BNF
Formulary
Red
 
   
 ....
 Non Formulary Items
Glasdegib Black Triangle  (Daurismo®)
(tablets)

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Non Formulary
Link  NICE TA646: Glasdegib with chemotherapy for untreated acute myeloid leukaemia (terminated appraisal)
 
Lapatinib  (Tyverb®)

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Non Formulary
High Cost Medicine
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
 
Necitumumab  (Portrazza®)

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Non Formulary
High Cost Medicine
Link  NICE TA411: Necitumumab for untreated advanced or metastatic squamous non-small-cell lung cancer
 
Pablociclib  (Ibrance®)

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Non Formulary
 
Ramucirumab  (Cyramza®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA403: Ramucirumab for previously treated locally advanced or metastatic non-small-cell lung cancer
 
Rociletinib

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Sonidegib  (Odomzo®)

View adult BNF View SPC online View childrens BNF
Non Formulary
 
Cytotoxic Drug  Temsirolimus  (Torisel®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
Link  NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
 
Cytotoxic Drug  Vandetanib  (Caprelsa®)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
Vosaroxin  (Qinprezo)

View adult BNF View SPC online View childrens BNF
Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine

Traffic Light Status Information

Status Description

Green

Suitable for prescribing by all in both primary and secondary care.  

Amber Recommended

Specialist recommended but suitable for continuation in primary care.  

Amber Initiation

Specialist initiated but suitable for continuation in primary care.  

Amber SCG

Specialist initiated and for continuation in primary care under a locally approved shared care guideline.  

Red

Suitable for prescribing in specialist settings (secondary care) only.   

Red Specialist Centre

Secondary care medicines to be used under specialised commissioning arrangements only.  

Blue

For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy.  

Black

Not recommended for use.  

netFormulary