| Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
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| Chapter Links... |
 Cancer Drugs Fund List |
| Details... |
| 08.01.05 |
Other antineoplastic drugs |
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Platinum compounds |
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Procarbazine |
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Protein kinase inhibitors |
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Afatinib
(tablet)
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Formulary
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NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
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Axitinib
(tablet)
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Formulary
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NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
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Bosutinib
(tablet)
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Formulary
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NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
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Brigatinib (Alunbrig®)
(tablet)
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Formulary
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NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
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Cabozantinib (Cabometyx®)
(tablet)
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Formulary
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NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
NICE TA516:Cabozantinib for treating medullary thyroid cancer
NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
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Ceritinib
(capsule)
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Formulary
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NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
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Crizotinib
(capsule)
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Formulary
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NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
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Dacomitinib (Vizimpro®)
(film coated tablets)
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Formulary
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NICE TA595 Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
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Dasatinib
(tablet)
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Formulary
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NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
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Erlotinib
(tablet)
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Formulary
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NICE TA227: Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer
NICE TA258: Erlotinib for the first-line treatment of locally advanced or metastatic EGFR-TK mutation-positive non-small-cell lung cancer
NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
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Everolimus (Afinitor®)
(tablet)
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Formulary
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NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
NICE TA432:Everolimus for advanced renal cell carcinoma after previous treatment
NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
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Everolimus (Votubia®)
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Formulary
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For use as per commissioning criteria set by NHS England
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Gefitinib
(tablet)
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Formulary
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NICE TA192: Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer
NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
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Ibrutinib (Imbruvica®)
(tablets)
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Formulary
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NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
NICE TA491:Ibrutinib for treating Waldenstrom’s macroglobulinaemia
NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
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Imatinib
(tablet)
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Formulary
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NICE TA209:Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
NICE TA425:Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
NICE TA70: Guidance on the use of imatinib for chronic myeloid leukaemia
NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
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Larotrectinib (Vitrakvi® )
(oral solution)
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Formulary
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NICE TA630: Larotrectinib for treating NTRK fusion-positive solid tumours
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Lorlatinib (Lorviqua®)
(tablet)
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Formulary
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NICE TA628: Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancer
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Neratinib (Nerlynx®)
(tablets)
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Formulary
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NICE TA612: Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab
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Nilotinib
(capsule)
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Formulary
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NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
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Nintedanib
(capsule)
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Formulary
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Vargatef branf for NSCLC, Ofev brand for IPF in line with NICE guidance (see links)
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NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
NICE TA379: Nintedanib for treating idiopathic pulmonary fibrosis
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Niraparib
(capsules)
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Formulary
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NICE TA528: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
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Osimertinib
(tablet)
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Formulary
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NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
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Palbociclib (Ibrance®)
(capsules)
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Formulary
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NICE TA495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
NICE TA619: Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
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Pazopanib
(tablet)
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Formulary
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NICE TA215: Pazopanib for the first-line treatment of advanced renal cell carcinoma
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Ponatinib
(tablet)
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Formulary
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NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
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Regorafenib (Stivarga® )
(tablet)
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Formulary
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NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
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Ribociclib (Kisqali®)
(tablets)
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Formulary
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NICE TA 496: Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
NICE TA593: Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
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Rucaparib (Rubraca®)
(tablets)
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Formulary
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NICE TA611: Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer
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Ruxolitinib (Jakavi®)
(tablet)
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Formulary
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NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
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Sorafenib
(tablet)
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Formulary
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NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
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Sunitinib
(capsule)
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Formulary
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NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma
NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours
NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
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Tivozanib
(capsules)
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Formulary
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NICE TA512:Tivozanib for treating advanced renal cell carcinoma
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Trametinib
(tablet)
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Formulary
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NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
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Vemurafenib
(tablet)
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Formulary
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NICE TA269: Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanoma
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Dabrafenib
(capsule)
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Formulary
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NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
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Taxanes |
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Topoisomerase I inhibitors |
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Trabectedin |
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Tretinoin |
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| Non Formulary Items |
Lapatinib (Tyverb®)
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Non Formulary
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NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
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Temsirolimus (Torisel®)
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Non Formulary
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NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
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Vandetanib (Caprelsa®)
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Non Formulary
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Key |
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Cytotoxic Drug
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Controlled Drug
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High Cost Medicine
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Traffic Light Status Information
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Description |
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Suitable for prescribing by all in both primary and secondary care. |
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Specialist recommended but suitable for continuation in primary care. |
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Specialist initiated but suitable for continuation in primary care. |
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Specialist initiated and for continuation in primary care under a locally approved shared care guideline. |
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Suitable for prescribing in specialist settings (secondary care) only. |
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Secondary care medicines to be used under specialised commissioning arrangements only. |
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For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital
pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy. |
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Not recommended for use. |
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