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Southampton Joint Formulary
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
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08.01.05  Expand sub section  Other antineoplastic drugs
08.01.05  Expand sub section  Platinum compounds
08.01.05  Expand sub section  Procarbazine
08.01.05  Expand sub section  Protein kinase inhibitors
Afatinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA310: Afatinib for treating epidermal growth factor receptor mutation-positive locally advanced or metastatic non-small-cell lung cancer
   
Axitinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA333: Axitinib for treating advanced renal cell carcinoma after failure of prior systemic treatment
   
Bosutinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA401: Bosutinib for previously treated chronic myeloid leukaemia
   
BrigatinibBlack Triangle (Alunbrig®)
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA571: Brigatinib for treating ALK-positive advanced non-small-cell lung cancer after crizotinib
   
Cabozantinib (Cabometyx®)
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA463 : Cabozantinib for previously treated advanced renal cell carcinoma
Link  NICE TA516:Cabozantinib for treating medullary thyroid cancer
Link  NICE TA542: Cabozantinib for untreated advanced renal cell carcinoma
   
CeritinibBlack Triangle
(capsule)
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Red
High Cost Medicine
 
Link  NICE TA395: Ceritinib for previously treated anaplastic lymphoma kinase positive non-small-cell lung cancer
Link  NICE TA500: Ceritinib for untreated ALK-positive non-small-cell lung cancer
   
Crizotinib
(capsule)
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Red
High Cost Medicine
 
Link  NICE TA406: Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer
Link  NICE TA422: Crizotinib for previously treated anaplastic lymphoma kinase-positive advanced non-small-cell lung cance
Link  NICE TA529: Crizotinib for treating ROS1-positive advanced non-small-cell lung cancer
   
Dacomitinib Black Triangle (Vizimpro®)
(film coated tablets)
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Formulary
Red
High Cost Medicine

 

 

 
Link  NICE TA595 Dacomitinib for untreated EGFR mutation-positive non-small-cell lung cancer
   
Dasatinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Erlotinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA227: Erlotinib monotherapy for maintenance treatment of non-small-cell lung cancer
Link  NICE TA258: Erlotinib for the first-line treatment of locally advanced or metastatic EGFR-TK mutation-positive non-small-cell lung cancer
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Everolimus (Afinitor®)
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA421: Everolimus with exemestane for treating advanced breast cancer after endocrine therapy
Link  NICE TA432:Everolimus for advanced renal cell carcinoma after previous treatment
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
Link  NICE TA498: Lenvatinib with everolimus for previously treated advanced renal cell carcinoma
   
Everolimus (Votubia®)
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Formulary
Red Specialist Centre
High Cost Medicine

For use as per commissioning criteria set by NHS England

 
   
Gefitinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA192: Gefitinib for the first-line treatment of locally advanced or metastatic non-small-cell lung cancer
Link  NICE TA374: Erlotinib and gefitinib for treating non-small-cell lung cancer that has progressed after prior chemotherapy
   
Ibrutinib (Imbruvica®)
(tablets)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA429 : Ibrutinib for previously treated chronic lymphocytic leukaemia and untreated chronic lymphocytic leukaemia with 17p deletion or TP53 mutation
Link  NICE TA491:Ibrutinib for treating Waldenstrom’s macroglobulinaemia
Link  NICE TA502: Ibrutinib for treating relapsed or refractory mantle cell lymphoma
   
Imatinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA209:Imatinib for the treatment of unresectable and/or metastatic gastrointestinal stromal tumours
Link  NICE TA326: Imatinib for the adjuvant treatment of gastrointestinal stromal tumours
Link  NICE TA425:Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
Link  NICE TA70: Guidance on the use of imatinib for chronic myeloid leukaemia
Link  NICE TA86: Imatinib for the treatment of unresectable and/or metastatic gastro-intestinal stromal tumours
   
LarotrectinibBlack Triangle (Vitrakvi® )
(oral solution)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA630: Larotrectinib for treating NTRK fusion-positive solid tumours
   
LorlatinibBlack Triangle (Lorviqua®)
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA628: Lorlatinib for previously treated ALK-positive advanced non-small-cell lung cancer
   
NeratinibBlack Triangle (Nerlynx®)
(tablets)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA612: Neratinib for extended adjuvant treatment of hormone receptor-positive, HER2-positive early stage breast cancer after adjuvant trastuzumab
   
Nilotinib
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA425: Dasatinib, nilotinib and high-dose imatinib for treating imatinib-resistant or intolerant chronic myeloid leukaemia
Link  NICE TA426: Dasatinib, nilotinib and imatinib for untreated chronic myeloid leukaemia
   
Nintedanib
(capsule)
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Red
High Cost Medicine

Vargatef branf for NSCLC, Ofev brand for IPF in line with NICE guidance (see links)

 
Link  NICE TA347: Nintedanib for previously treated locally advanced, metastatic, or locally recurrent non‑small‑cell lung cancer
Link  NICE TA379: Nintedanib for treating idiopathic pulmonary fibrosis
   
Niraparib
(capsules)
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Red
High Cost Medicine
 
Link  NICE TA528: Niraparib for maintenance treatment of relapsed, platinum-sensitive ovarian, fallopian tube and peritoneal cancer
   
Osimertinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA416: Osimertinib for treating locally advanced or metastatic EGFR T790M mutation-positive non-small-cell lung cancer
   
PalbociclibBlack Triangle (Ibrance®)
(capsules)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
BlueTeq
 
Link  NICE TA495: Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA619: Palbociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
   
Pazopanib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA215: Pazopanib for the first-line treatment of advanced renal cell carcinoma
   
Ponatinib
(tablet)
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Red
High Cost Medicine
 
Link  NICE TA451 : Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia
   
Regorafenib (Stivarga® )
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA488: Regorafenib for previously treated unresectable or metastatic gastrointestinal stromal tumours
Link  NICE TA555: Regorafenib for previously treated advanced hepatocellular carcinoma
   
RibociclibBlack Triangle (Kisqali®)
(tablets)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA 496: Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer
Link  NICE TA593: Ribociclib with fulvestrant for treating hormone receptor-positive, HER2-negative, advanced breast cancer
   
RucaparibBlack Triangle (Rubraca®)
(tablets)
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Formulary
Red
High Cost Medicine
Cancer Drugs Fund
 
Link  NICE TA611: Rucaparib for maintenance treatment of relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer
   
Ruxolitinib (Jakavi®)
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA386: Ruxolitinib for treating disease-related splenomegaly or symptoms in adults with myelofibrosis
   
Sorafenib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA474: Sorafenib for treating advanced hepatocellular carcinoma
Link  NICE TA535: Lenvatinib and sorafenib for treating differentiated thyroid cancer after radioactive iodine
   
Sunitinib
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA169: Sunitinib for the first-line treatment of advanced and/or metastatic renal cell carcinoma
Link  NICE TA179: Sunitinib for the treatment of gastrointestinal stromal tumours
Link  NICE TA449 : Everolimus and sunitinib for treating unresectable or metastatic neuroendocrine tumours in people with progressive disease
   
Tivozanib
(capsules)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA512:Tivozanib for treating advanced renal cell carcinoma
   
Trametinib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA396: Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
Vemurafenib
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA269: Vemurafenib for treating locally advanced or metastatic BRAF V600 mutation‑positive malignant melanoma
   
Dabrafenib
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA321:Dabrafenib for BRAF V600 +ve melanoma
Link  NICE TA396:Trametinib in combination with dabrafenib for treating unresectable or metastatic melanoma
Link  NICE TA544:Dabrafenib with trametinib for adjuvant treatment of resected BRAF V600 mutation-positive melanoma
   
08.01.05  Expand sub section  Taxanes to top
08.01.05  Expand sub section  Topoisomerase I inhibitors
08.01.05  Expand sub section  Trabectedin
08.01.05  Expand sub section  Tretinoin
 ....
 Non Formulary Items
Lapatinib  (Tyverb®)

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Non Formulary
High Cost Medicine
Link  NICE TA257: in combination with an aromatase inhibitor for HER2 positive metastatic breast cancer
 
Cytotoxic Drug  Temsirolimus  (Torisel®)

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Non Formulary
High Cost Medicine
Link  NICE TA178: Bevacizumab (first-line), sorafenib (first- and second-line), sunitinib (second-line) and temsirolimus (first-line) for the treatment of advanced and/or metastatic renal cell carcinoma
 
Cytotoxic Drug  Vandetanib  (Caprelsa®)

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Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine

Traffic Light Status Information

Status Description

Green

Suitable for prescribing by all in both primary and secondary care.  

Amber Recommended

Specialist recommended but suitable for continuation in primary care.  

Amber Initiation

Specialist initiated but suitable for continuation in primary care.  

Amber SCG

Specialist initiated and for continuation in primary care under a locally approved shared care guideline.  

Red

Suitable for prescribing in specialist settings (secondary care) only.   

Red Specialist Centre

Secondary care medicines to be used under specialised commissioning arrangements only.  

Blue

For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy.  

Black

Not recommended for use.  

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