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Southampton Joint Formulary
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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
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08.02.04  Expand sub section  Other immunomodulating drugs
Alemtuzumab
(injection)
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Formulary
Red
High Cost Medicine
NHS England
BlueTeq

For multiple sclerosis and used off-label for allogeneic BMT and peripheral blood SCT

 
Link  EMA Safety Update: Use of alemtuzumab restricted while review is ongoing Apr 2019
Link  NHS England Urgent Clinical Commissioning Policy Statement: Alemtuzumab for treating relapsing-remitting multiple sclerosis - third cycle (all stages) Aug 2018
Link  NICE TA312: Alemtuzumab for relapsing‑remitting multiple sclerosis
   
BCG bladder instillation
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Formulary
Red
 
   
CemiplimabBlack Triangle (Libtayo)
(injection)
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Formulary
Red
Cancer Drugs Fund
 
Link  NICE TA592: Cemiplimab for treating metastatic or locally advanced cutaneous squamous cell carcinoma
   
Dimethyl fumarate (Tecfidera®)
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA320: Dimethyl fumarate for multiple sclerosis
   
Fingolimod
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA254: Fingolimod for highly active relapsing remitting multiple sclerosis
   
Glatiramer acetate
(injection)
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Formulary
Red
High Cost Medicine

Restricted Item Specialist use only for multiple sclerosis

 
Link  NICE TA32: Beta interferon and glatiramer acetate for the treatment of multiple sclerosis
Link  NICE TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Mifamurtide
(injection)
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Formulary
Red
 
Link  NICE TA235: Mifamurtide for the treatment of osteosarcoma
   
Natalizumab
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA127: Natalizumab for the treatment of adults with highly active relapsing–remitting multiple sclerosis
   
OcrelizumabBlack Triangle (Ocrevus®)
(injection)
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Formulary
Red
High Cost Medicine
BlueTeq
 
Link  NICE TA533: Ocrelizumab for treating relapsing–remitting multiple sclerosis
Link  NICE TA585: Ocrelizumab for treating primary progressive multiple sclerosis
   
Teriflunomide
(tablet)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA303: Teriflunomide for treating relapsing–remitting multiple sclerosis
   
08.02.04  Expand sub section  Interferon Alfa
Interferon Alfa
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
   
Peginterferon Alfa-2a (Pegasys®)
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA106: Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Peginterferon alfa and ribavirin for treating chronic hepatitis C in children and young people
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA96: Adefovir dipivoxil and peginterferon alfa-2a for the treatment of chronic hepatitis B
   
Peginterferon Alfa-2b (ViraferonPeg®)
(injection)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA200: Peginterferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA300: Interferon alfa and ribavirin for the treatment of chronic hepatitis C
Link  NICE TA75: Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C
   
08.02.04  Expand sub section  Interferon beta
Interferon Beta
(injection)
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Formulary
Red
High Cost Medicine

For use as per specialist commissioning criteria

 

Restricted Item Not for use in Covid-19 treatment outside of clinical trials. Seek further advice from infection control specialist/pharmacy team.

 
Link  NHS England/UK Chief Medical Officers’ joint letter: Novel coronavirus: clinical trials April 2020
Link  NICE TA32: Beta interferon and glatiramer acetate for the treatment of multiple sclerosis
Link  NICE TA527: Beta interferons and glatiramer acetate for treating multiple sclerosis
   
Peginterferon Beta-1a (Plegridy®)
(injection)
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Formulary
Red
High Cost Medicine

Restricted Item Specialist use only

 
Link  NICE TA624: Peginterferon beta-1a for treating relapsing–remitting multiple sclerosis
   
08.02.04  Expand sub section  Aldesleukin
08.02.04  Expand sub section  Lenalidomide, pomalidomide, and thalidomide to top
Lenalidomide ( Revlimid®)
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA171: Lenalidomide for the treatment of multiple myeloma in people who have received at least one prior therapy
Link  NICE TA322: Lenalidomide for treating myelodysplastic syndromes associated with an isolated deletion 5q cytogenetic abnormality
Link  NICE TA586: Lenalidomide plus dexamethasone for multiple myeloma after 1 treatment with bortezomib
Link  NICE TA587: Lenalidomide plus dexamethasone for previously untreated multiple myeloma
Link  NICE TA627: Lenalidomide with rituximab for previously treated follicular lymphoma
   
Pomalidomide (Imnovid®)
(capsule)
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Formulary
Red
High Cost Medicine
 
Link  NICE TA427: Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib
   
Thalidomide
(capsule)
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Formulary
Red
High Cost Medicine

Also for renal cell carcinoma

 
Link  NICE TA228: Bortezomib and thalidomide for the first‑line treatment of multiple myeloma
   
 ....
 Non Formulary Items
Aldesleukin  (Proleukin®)

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Non Formulary
High Cost Medicine
 
Canakinumab  (Ilaris®)

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Non Formulary
High Cost Medicine
 
Cediranib  (Recentin®)

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Non Formulary
 
Cobimetinib  (Cotellic®)

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Non Formulary
Link  NICE TA414: Cobimetinib in combination with vemurafenib for treating unresectable or metastatic BRAF V600 mutation-positive melanoma
 
Dinutuximab  (Unituxin®)

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Non Formulary
 
Fampridine

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Non Formulary
High Cost Medicine
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine

Traffic Light Status Information

Status Description

Green

Suitable for prescribing by all in both primary and secondary care.  

Amber Recommended

Specialist recommended but suitable for continuation in primary care.  

Amber Initiation

Specialist initiated but suitable for continuation in primary care.  

Amber SCG

Specialist initiated and for continuation in primary care under a locally approved shared care guideline.  

Red

Suitable for prescribing in specialist settings (secondary care) only.   

Red Specialist Centre

Secondary care medicines to be used under specialised commissioning arrangements only.  

Blue

For primary care, either via FP10 or supplied through specialist services. These products may be stocked by hospital pharmacies only for supply to primary care units/wards or for continuing supplies for patients admitted on therapy.  

Black

Not recommended for use.  

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